New research on mice has shown that “remodeling” unhealthy microbiome into healthy microbiome can avoid chronic diseases by improving cholesterol. Everyone can reply in private letter: Diabetes, join our offline diabetes management group, get more professional diabetes and other health knowledge guidance, and learn diabetes management and intestinal flora care knowledge!
- Use peptides to adjust intestinal microbes
Using peptides, scientists turn an unhealthy gut microbiome into a healthy gut, which helps lower cholesterol. They say that this may help defend against certain diseases.
They published their research results at the American Chemical Society’s Fall 2019 National Conference and Expo, which was held in San Diego, California.
The researchers studied a certain type of molecule and how it interacts and changes with the gut microbiome.
Professor M. Reza Ghadiri and the research team from the Scripps Research Institute in La Jolla, California, were able to change intestinal bacteria in such a way that they can positively affect cholesterol levels in mice, especially when they eat high Arterial plaque occurs when fat is present.
- Peptides and gut microbiome
Professor Ghadiri and colleagues used mice called LDL receptor knockout mice, which is the gold standard when studying statins. These are drugs that lower cholesterol in the body.
The molecule used by the scientists is a peptide called self-assembled cyclic D peptide, L-α-peptide, which Professor Ghadiri developed in the laboratory to kill harmful bacteria.
Peptides are the building blocks of proteins, but self-assembled cyclic D peptides and L-α-peptides do not occur in nature. The researchers also developed them to interact specifically with different types of bacteria in some way.
“Our hypothesis is that if we can use our peptides to selectively regulate the growth of certain bacteria in the gut microbiome instead of killing them, then more beneficial bacteria will grow to fill the niche and the gut The Tao will be’reshaped’ into a very healthy state.” Professor Ghadiri said.
“Our theory,” he added, “this process can prevent the occurrence or development of certain chronic diseases.”
- Good research results of peptides
In order to make suitable peptides, the scientists developed a large-scale screening test and selected two optimal peptides after testing with a representative mouse microbiome in the laboratory.
The study consisted of three groups of mice:
A person accepted a low-fat diet.
A person receives a typical Western (high fat) diet.
A person accepts a Western diet plus one of the two peptides listed above.
Before and after the dietary intervention, the team sequenced the gut microbiome of stool samples from all three mouse groups. They also examined their arterial plaque and measured molecules, which can affect metabolism, inflammation, and the immune system itself.
Professor Ghadiri and the research team found that these peptides have a significant effect on the arterial health of mice.
“The total cholesterol in plasma of mice fed with Western diet and peptides was reduced by 50%. Compared with mice without peptides in Western diet, there were no obvious plaques in the arteries.” Professor M. Reza Ghadiri said.
“We have also seen inhibitory levels of molecules increase inflammation and rebalance the levels of disease-related metabolites. These mice are similar to a low-fat diet.”
- Potential applications in humans
Regarding the possible mechanisms behind the research results, Professor Ghadiri explained that they may be due to the influence of bile acids, which can affect the metabolism of cholesterol. It may also involve genes that affect atherosclerosis, which is an inflammatory process.
Although this study involves rats, it may be an important stepping stone to help change the human gut microbiome, despite their different diets.
This study looks at some aspects of cardiovascular disease and also reveals the relationship between plasma cholesterol and the development of atherosclerosis.
“This is the first time in history that someone has indicated that molecules have purposefully transformed the gut microbiome and turned [unhealthy] gut into a healthier gut,” Professor Ghadiri pointed out.